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Monday, December 22, 2014

Metronidazole Anti-Infective Medication. Treatment of Infections

Posted by William on June 26, 2009

Metronidazole exists as a nitroimidazole anti-infective prescription drugs, mostly used in the treatment of infections from susceptible organisms, in particular anaerobic protozoa and bacteria. It is regarded as the superior form of anti-anaerobic medications.

In America it is sold as the brand name Flagyl, and as generic version Metronidazole around the world with this same brand name, Flagyl. Also made by some generic manufacturers, it can be bought at reasonably low prices.

Uses
Metronidazole prescription medication usage helps to treat the following:

* Lower respiratory tract infections (together with another agent with activity against microaerophilic Streptococcus)
* Adjunct treatment for gastritis and duodenal ulcer associated with Helicobacter pylori
* Intra-abdominal infections, including peritonitis, intra-abdominal abscess, and liver abscess
* Skin and skin structure infections
* Bone and joint infections
* Bacterial septicemia
* Endocarditis
* Gynecologic infections (endometritis, endomyometritis, tubo-ovarian abscess, and post-surgical vaginal cuff infection)
* Central nervous system infections (meningitis and brain abscess)
* Bacterial vaginosis
* Giardiasis
* Trichomoniasis
* Amebiasis

Mechanism of action

Metronidazole fights aerobic bacterium by using the electron transport protein ferrodoxin, and reducing it. Next this substance attaches to DNA, and breakdown of DNA begins to occur. In vitro results indicate that metronizadole possesses antioxidant properties and could avert or treat rosacea signs.

Advantages

Metronidazole’s advantages include:

* Large percent of Gram-negative anaerobes that are sensitive
* Dosage forms in IV and oral
* Properties of quick killing of bacteria
* Penetrates tissues well
* Considerably low chance of induction of C. difficile colitis
* cost

Disadvantages

* Metronidazole hydroxy compound can be cancer-causing. In addition, metronidazole has been demonstrated to cause cancer in animals. Needless use of this medication is not advisable.
* Taking alcohol while using metronidazole can cause a disulfiram-like reaction with  effects that can include vomiting, nausea, the flushing of the skin, tachycardia  (accelerated heart rate), shortness of breath, and even possible death. Alcoholic beverages are not advised while being treated with systemic metronidazole and in the day following  the therapy.
* Severe toxic reaction leads to problems with the digestive tract. Unabated toxicity may induce neurological deterioration. A chance of convulsive seizure episodes and peripheral neuropathy exists.